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However, even a 50% reduction in worm burden would decrease the human health problems caused by schistosomiasis, and a combination of auranofin (or another TGR inhibitor) with an agent that works by a different mechanism might be more effective and would also reduce the chances of the parasite developing drug resistance

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Assessment of cell viability Unless indicated otherwise, 2 10 3 MF or 4 10 3 human cells were seeded in 96-well plates and treated with the corresponding compounds as indicated in figures and figure legends

380 An experimental model fed with diet lack of prebiotic fiber induces hypertension through inducing deficiency of SCFA production and GPR43/109A signaling, suggesting the underlying mechanisms of dietary fiber