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In studies on mice with gastric cancer induced by 1-methyl-3-nitro-1-nitrosoguanidine, stachydrine inhibited histone deacetylase (HDAC) activity in gastrointestinal tissues, significantly decreasing oxidative stress markers and cytokine levels

Lancet 380 , 21292143 (2012)

Furthermore, since reduced metals can actively propagate radical chains by reducing hydroperoxides to RO, it is worth investigating whether high FRAP values correlate with the potential of polyphenols to act as pro-oxidants under certain conditions

Combining quantitative analyses with mathematical modelling, we demonstrate that morphological alterations of the glomerular filtration barrier lead to reduced compressive forces that counteract filtration pressure, thereby resulting in capillary dilatation, and ultimately albuminuria