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In accordance with the metabolome data, we observed different accumulations of the metabolites (or their derivatives), including cinnamic acid, p-coumaric acid, p-coumaroylquinic acid, Caffeoyl quinic acid, p-coumaroylshikimic acid, caffeic acid, chlorogenic acid, ferulic acid, coniferin, sinapic acid, syringin, naringenin, prunin, luteolin, and kaempferol in Xcc -infected samples of the R line compared with the Xcc -infected samples of the S line ( Supplementary Table 2 )

From an environmental point of view, this is important because long-term exposures to MeHg in experimental studies better represent the chronic exposure in humans, who are normally exposed to the neurotoxicant for months or years

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Furthermore, revision surgery due to implant loosening or insufficient stabilization was required in 15% of patients