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Sec-Gpxs are able to use Trx, and C-Gpxs GSH, but the rate of reaction is significantly decreased for the non-preferred substrate

Bykov VJN, Zhang Q, Zhang M, Ceder S, Abrahmsen L, Wiman KG targeting of mutant p53 and the Cellular Redox Balance by APR-246 as a strategy for efficient cancer therapy

Its role appears modulatory rather than suppressive, supporting coordinated neural and endocrine timing rather than inducing forced sleep states

SLC38A1 exhibits upregulated expression in breast cancer [62], gastric cancer [63], CRC [64], lung cancer [65], hepatocellular carcinoma [66] and melanoma [67], displaying a strong correlation with enhanced proliferation