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As researchers continue to explore innovative solutions, medications like Tesofensine and GLP-1 agonists have emerged as potential game-changers in the field of weight loss

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We included each participants body temperature time-of-day variables (average B1 and B2) in adjusted models to hold constant the average effect of time of day for each participants average body temperature

Week 1: 50mcg nightly Week 2: 100mcg nightly (if Week 1 tolerated well) Weeks 3-4: 150mcg nightly (if no adverse effects) Weeks 5-8: 200-300mcg nightly (target maintenance dose) Gradual titration helps identify your minimum effective dose while avoiding unnecessary exposure to higher amounts