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N -acetylcysteine has been shown to reduce IL-6 levels in hemodialysis patients,18 although no change in these levels were reported following NAC treatment in a rat model of traumatic brain injury.19 Conversely, increased TNF- and IL-1 levels were reduced following NAC treatment in rat models of both traumatic brain injury and focal cerebral ischemia.19,20 N -acetylcysteine has also been shown to improve outcomes in lipopolysaccharide models of inflammation

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As a master regulator in hypoxia and ischemia, HIF-1 not only can rapidly respond to hypoxia, but also is activated by several non-hypoxic stimuli, such as inflammatory mediators or cytokines 35