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Dai W, Xu L, Yu X, Zhang G, Guo H, Liu H, et al

Oxidative stress and inflammation biomarkers in MASLD Oxidative stress and inflammation play pivotal roles in the pathogenesis of MASLD [96, 97]

Blood 116 , 10701078 (2010)

ARA-290 received FDA Orphan Drug Designation for this indication TRPV1-mediated pain models ARA-290 demonstrated specific inhibition of TRPV1 channel activity, relieving capsaicin-induced mechanical hypersensitivity in pre-clinical nociceptor models Complex Regional Pain Syndrome (CRPS) investigational studies have examined ARA-290 in CRPS models due to its dual anti-inflammatory and nociceptor-targeting mechanism Chronic neuropathic pain multiple studies confirm ARA-290 reduces neuroinflammation in the spinal cord by suppressing TNF-, IL-1, and other pro-inflammatory cytokines that maintain chronic pain states Neuroprotection and CNS Research: Cerebral ischaemia/stroke models Wang et al