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As this study comprehensively evaluated how microbes and their derived metabolites alter gut physiology by direct CNS-mediated gut sympathetic modulation, separate research implicates the role of the aryl hydrocarbon receptor (AHR) as a critical node in regulating gut physiology and neurogenesis (Obata et al., 2020

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ROS originate from both endogenous sources (e.g., inflammation and infection) and exogenous exposures (e.g., lifestyle and environmental pollutants)