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Dillmann, W

Vitale C, Ciccone M, Hinojosa C, Keating MJ, Pemmaraju N, O'Brien S, Wierda WG, Thomas DA, Borthakur G , Ohanian M, Burger JA, Ferrajoli A

10.3389/fpsyt.2024.1295766 Front Psychiatry 112 MaesM.TwiskF

However, dysfunction of IDO2 in combination with tryptophan inhibition of IDO1 results in increased cytosolic tryptophan, reduced kynurenine production and downstream metabolites including quinolinate and NAD +