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doi: 10.1016/j.cca.2020.04.019 78 MurakamiMRhayemYKunzkeTSunNFeuchtingerALudwigPet al

and the main findings of ferroptosiss promotion/inhibition of immunogenic cell death, remodeling effect on the tumour microenvironment, and synergistic effect of combination therapy, as well as the limitations of the experimental model (e.g., lack of clinical verification) and unresolved scientific questions

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Graphical Abstract The occurrence of TECs ferroptosis in CKD is due to an imbalance in iron and lipid regulation, which drives the occurrence of lipid peroxidation and the accumulation of lipid hydroperoxide