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607 Clausenamide, an alkaloid isolated from Clausena lansium , interacts directly with Ser663 of ALOX5, blocking the nuclear translocation of ALOX5, alleviating lipid peroxide accumulation and ferroptosis in dopaminergic neurons, significantly improving behavioral deficits in PD mouse models, and providing an attractive strategy for PD treatment

4 Ferroptosis defense systems 4.1 SLC7A11-GSH-GPX4 axis The main barrier that inhibits the path of ferroptosis is the redox of the cell, which is that it can instantly remove membrane phospholipid peroxide