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Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, et al

The classically activated M1-macrophages comprise immune effector cells with an acute inflammatory phenotype

52 In 2023, the Nobel Prize in Physiology and Medicine was awarded to Katalin Kariko and Drew Weissman for pioneering nucleoside base modification technology to decrease mRNA immunogenicity, further highlighting the critical role of chemical modification technologies in developing mRNA vaccines