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NOX family members normally regulate cellular physiological functions, but under abnormal circumstances contribute to the pathogenesis of cell/tissue damage associated with infections and vascular disorders (Panday et al., 2015)

Although most irAEs are identified during pre-clinical development, the spectrum, timing and outcomes were only recently investigated through real-world, large-scale pharmacovigilance analyses like the spontaneous reporting systems that looked at the real-time monitoring of these drugs safety profiles [16]

doi: 10.1016/j.ceca.2024.102854, 35 DengY.YaoY.WangY.YuT.CaiW.ZhouD.et al

Overcoming challenges in treating autoimmuntity: Development of tolerogenic immune-modifying nanoparticles