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An intermediate research compound, AOD9401, was studied in parallel and contributed substantially to the mechanistic literature during this period

MTFR1L is a mitochondrial outer membrane-localized protein that regulates mitochondrial morphology and is essential for stress-induced AMPK-dependent mitochondrial fragmentation (Tilokani et al., 2022)

The reduction of ROS will enhance the translocation of -catenin, upregulating the stemness-related genes (KFL4, NANOG, OCT4, SOX2, CD13, and CD44) in HCC (Li et al., 2019)