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Some metabolic enzymes, such as succinate dehydrogenase (SDH), fumarate hydratase (FH), IDH and pyruvate kinase 2 (PKM2) are likely to activate HIF-1 pathway by stabilizing HIF-1, therefore enhancing cancer metastasis (258)

Because when I go to the literature now it's a little bit tough because the cadavers that you looked at in medical school, not all of them are processed on the same timeline

2012;302:G1171G1179

The goal of tertiary chemotherapy, on the other hand, is to stop the progression of an existing disease or the development of a new (second) primary disease in people who have already undergone potentially curative therapy