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Hyperglycemia, increased sorbitol and protein kinase C, elevated homocysteine, reduced nitric oxide and excessive Reactive Oxygen Species (ROS) damage endothelial tissue and produce a rheological change that increases vascular resistance and reduces blood flow to the nerve 3.3 Risk factors Diabetes is the strongest risk factor for DPN, along with certain disease characteristics such as diabetes duration and poor glycemic control in terms of fasting blood glucose (FBG), glycated hemoglobin (HbA1c

doi: 10.1038/s41591-018-0136-1 40 HoshidaYBrunetJPTamayoPGolubTRMesirovJP

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As such, just like with most any non-ruminant (except those coprophagic animals I mentioned above), baby calves and baby lambs (any newborn ruminant animal, from bison to deer) need to get their vitamin B12 directly from a source that already has enough vitamin B12 in it