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Derivatives thereof A61K38/46Hydrolases (3) A61K38/48Hydrolases (3) acting on peptide bonds (3.4) A61K38/482Serine endopeptidases (3.4.21) A61K38/4846Factor VII (3.4.21.21)

Overcoming resistance to checkpoint blockade therapy by targeting PI3K in myeloid cells

Pathol Res Pract (2017) 213(6):62633

cGAMP binds to and activates the endoplasmic reticulum transmembrane receptor STING, finally resulting in the production and release of type I interferons (IFN), which are potent anti-viral and anti-cancer cytokines (136)