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Necrosis and/or apoptosis of exocrine pancreatic tissues in the CYP + R group may result from increased ROS and MDA concentrations, as well as lower GSH and GST concentrations and increased levels of pro-inflammatory markers such as TNF- [58]

In cohort 1, 9 eyes showed substantial improvement in MMS and heatmaps (Figure 6, AH, and Supplemental Figures 5, 7, 8, 9, 11, 12, 13, and 14) and 9 eyes showed little change or worsening (Supplemental Figures 3, 4, 6, 10, 15, 16, 17, 18, and 19)