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Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex

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There is a high prevalence of migraine among close relatives with CVS and both often respond to similar medications.15, 56, 57 Given the links between these two disorders, mitochondrial supplements have been used in the prophylaxis of CVS