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this finding is consistent with that of another study, that is, the activation of the MAPK pathway (e.g., ERK1/2 activation) is involved in ER stress, cell proliferation, cell cycle arrest, and autophagy 38

Studies show it can significantly lower inflammatory signaling and neutrophil activity in models of acute inflammation ( Getting et al., 2003, J Pharmacol Exp Ther ), while broader reviews highlight its potential as a non-pigmenting, anti-inflammatory peptide for skin and gut repair ( Brzoska et al., 2008, Endocr Rev )

In the event of infection, neutrophils are swiftly activated and produce ROS, which may contribute to decondensing mitochondrial and cellular DNA