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Rinaldi A, et al

EVs, including exosomes (30150 nm), microvesicles (1001,000 nm), and apoptotic bodies (5005,000 nm), are lipid-based nanocarriers released via distinct biogenetic pathways (Ngo et al., 2025

GCLM interacts with GCLC, making the GCL holoenzyme kinetically more efficient in glutathione synthesis since GCLC has a very high Km for l-glutamate compared to when it is complexed with GCLM 32,33