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"It's preliminary, but you can see that countries that have more ergothioneine in their diets, countries like France and Italy, also have lower incidences of neurodegenerative diseases, while people in countries like the United States, which has low amounts of ergothioneine in the diet, have a higher probability of diseases like Parkinson's Disease and Alzheimer's ," said Beelman

This approach may not fully capture the functional diversity within each phylotype, and we couldnt validate the predicted functions involving uncultured microbes

Notably, NADPH depletion sensitizes fibrosarcoma HT-1080 cells to ferroptosis inducers, indicating that NADPH is negatively associated with ferroptosis sensitivity (48)

All I can give you is my take on the issue