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ROS/reactive intermediates such as H 2 O 2 and lipid hydroperoxides interact with specific amino acids, arginine, lysine, proline or threonine, causing protein-protein cross-linkages, resulting in protein denaturation and loss of activity

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In Erastin-induced ferroptosis, the expression of lysosome-associated membrane protein 2a (LAMP2a) is increased, which promotes heat shock protein 90 (HSP90)-dependent autophagy, which in turn mediates the degradation of GPX4[67]