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Furthermore, SCFAs might regulate energy homeostasis through binding to the G protein-coupled receptors (GPCRs), GPR41 and GPR43, on intestinal epithelial cells (53), resulting in enhanced production and secretion of gut hormones (56), namely, peptide YY (PYY) (59) and glucagon-like peptides 1 and 2 (GLP-1 and GLP-2) (60)