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In addition, polyamines regulate the Wnt/-catenin signaling pathway through spermidine/spermidine-N (1) -acetyltransferase (SSAT) activity, further promoting tumor proliferation (Wang et al., 2017)

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Internal mitochondrial changes and external environmental factors can disrupt the, ETC, leading to mtROS overproduction due to electron leakage (Palma et al., 2024)