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We and others previously showed that human and rodent -cells express critical components of the catecholamine biosynthetic machinery including tyrosine hydroxylase (TH), Dopa decarboxylase (DDC), and the vesicular monoamine transporter (VMAT), allowing these cells to produce, package and secrete DA 6,7,9,37,38,39

Research has explored effects on adipocyte metabolism, energy balance parameters, and downstream NAD+-dependent signalling pathways

The inhibition of NNMT can influence several intracellular processes within experimental systems: Altered nicotinamide metabolism through reduced methylation of nicotinamide

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