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Phase II trial data published in the New England Journal of Medicine (2023) demonstrated meaningful weight reduction in adults with obesity, but the drug has not completed the full regulatory pathway required for MHRA or EMA approval and does not hold a UK marketing authorisation

Of note, 25% of our cohort met eligibility criteria for a recent semaglutide trial in obese non-diabetics with pre-existing cardiovascular disease

Within this pathological framework, obesity is not merely a downstream consequence of elevated prolactin levels, but may promote increased prolactin secretion

10.1038/srep09102 335 ZhuC.LiJ.LiuC.ZhouP.YangH.LiB