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The resultant oxidative stress induces macromolecular oxidation of proteins, lipids and DNA/RNA, leading to lipid peroxidation of biomembranes, denaturation of intracellular proteins and enzymes and DNA damage

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Brain Res 1410:141151

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Transglutaminase 2 crosslinks the glutathione S-transferase tag, impeding proteinprotein interactions of the fused protein

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