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Other new agents are undergoing clinical trials, such as MOR202 (Felzartamab) (fully human) [59], TAK079 (Mezagitamab) (fully human) [60], FTL004 (humanized Ig1) [61], SAR442085 (fully human engineered) [62] and TNB-738 (fully human) [63]

Studies have shown that certain types of B12 including methylcobalamin, adenosylcobalamin, and hydroxycobalamin (6) are preferred over the more common and synthetic form of B12 known as cyanocobalamin

The British National Formulary (BNF) provides full clinical information on hydroxocobalamin

Conclusion There is a growing body of evidence suggesting that onabotulinumtoxinA is a safe and effective treatment for TN