glutathione for leukemia S-Transferase mu 1/GSTM1 Antibody JCI - Dual targeting of

High intracellular GSH is associated with drug resistance by promoting drug conjugation and transport-mediated efflux

Ghosal S, Sinha B

While BCL-2 protein expression upon CB-839 treatment remained stable even at maximal concentrations of 100 M, MCL-1 protein levels increased in both cell lines in cells incubated with CB-839 compared with control cells, indicating that the HG-3 and MEC-1 cells had an MCL-1 protein dependency in response to apoptotic stimuli ( Supplemental Figure 3 )

However, the determination of Mn-SOD and Cu, Zn-SOD will provide more information, since the location and response of different SODs differ