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The liver contains the greatest diversity and quantity of metabolic enzymes involved in the biotransformation of drugs, and thus the majority of drug metabolism occurs in the liver

Randomization was carried out using a minimization approach [Pocock and Simon (1975)] using the following factors: gender, ECOG PS (0 versus 1), response to prior chemotherapy (complete or partial response versus stable disease), history of brain metastases (yes versus no), non-platinum component of induction therapy (docetaxel versus gemcitabine versus paclitaxel), and disease stage (IIIb versus IV)

A delay in accurate diagnosis and treatment can lead to long-term vision impairment

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