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EVs derived from M2-polarized microglia have been shown to improve learning and memory in both 5FAD mice and an AD model induced by intracerebroventricular A142 injection, with efficacy demonstrated in the NORT, Morris water maze, Y-maze, and OFT [102-103]

of blood with 0.75 vol

We describe the inward-facing structure as substrate-free rather than apo, as we observe weak, non-proteinaceous density in the cleft between the two domains (Supplementary Fig