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Adding a stimulant's appetite-suppressing effects on top of age-related malabsorption creates a compounding risk

Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury

Molecules 22 , 388 (2017)

On the other hand, under specific pathophysiological conditions (e.g., low-dose exposure or acute stress), TMAO activates endoplasmic reticulum (ER) stress-protective pathways or upregulates antioxidant enzyme expression, demonstrating a potential compensatory effect on myocardial tissue