glutathione melanin production The redox cycle, demonstrating the inter-conversion of Glutathione Trisulphide Improves Skin Brightness

It is a tightly regulated reaction that depends on both the availability of the amino acids (cysteine, glycine, and glutamate) and the rate-limiting enzyme, glutamate-cysteine ligase ( GCL )

After centrifugation, the supernatant was transferred to a new EP tube and dried, followed by derivatization reagent treatment

It may be present in the form of reduced thiol (GSH), as well as oxidized disulfide (GSSG)

Enhancing GSH, mainly through NAC, GSH precursors rich in cysteine (whey protein, whey protein isolate rich in cysteine) or pro-GSH compound administration, becomes a potential treatment option for inflammatory diseases by reducing oxidative stress and cytokine expression especially in diabetic patients that also are at risk of more severe COVID-19 disease (299)