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Glucose metabolism disruptions occur not only in pathology but also with aging, marked by metabolic abnormalities and bioenergetic dysregulation [72]

HMOX activity was determined by measurements of CO production using gas chromatography with a reduction gas analyzer (Peak Instruments, Menlo Park, CA, USA) as described previously.21 HMOX activity was calculated as pmol CO/h/mg of protein

It showed similar tendency with MDA contents, suggesting that a lower degree of lipid peroxidation is closely associated with a higher level of anti-oxidant enzyme activity