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Furthermore, disease-associated changes in active histone marks such as H3K27ac and H3K4me3 correlate with transcriptional shifts in reactive astrocytes, particularly in genes associated with synaptic dysfunction, tau pathology and A processing

In acute-on-chronic liver failure (ACLF), midodrine titrated to increase mean arterial pressure by 8.5 mmHg reduced HVPG, highlighting its role in critical portal hypertension management 115