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The extracellular regulated protein kinases (ERK) signaling pathway, activated by high glucose, catalyzes the phosphorylation of downstream products such as TGF-

(PubMed) Khalili M, Soltani M, Moghadam SA, Dehghan P, Azimi A, Abbaszadeh O

Its worth noting that the cocrystal structure of compound 16, when bound to SjGST, clearly shows that its binding mode considerably overlaps with IBZGSH at the H-site, thus significantly differing from known GSH-like compounds

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