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Conversely, symptoms suggesting excessive thyroid hormone replacement (hyperthyroidism), including palpitations, tremor, anxiety, heat intolerance, or insomnia, particularly in the context of significant weight loss, warrant evaluation and possible levothyroxine dose reduction

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In PD, dopaminergic information transmitted by dopaminergic neurons decreases, while glutamatergic signaling in the basal ganglia increases and stimulates the release of dopamine through surviving dopaminergic neurons in the SNpc as a compensatory mechanism

doi: 10.1007/s00441-006-0266-5 73 GelbTPshenichkinSRodriguezOCHathawayHAGrajkowskaEDiRaddoJOet al