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The cytotoxicity of these GSH conjugates depends essentially on GST and gamma-glutamyl transferases (GT), the enzymes which initiate the mercapturic acid synthesis pathway

Miyashita A, Ito J, Parida IS, Syoji N, Fujii T, Takahashi H, et al

In maturation, M2 competitively binds Beclin 1 (BECN1), Autophagy-Related Gene 5 (ATG5), and LC3B (a subtype of LC3) to block autophagosomelysosome fusion (67), leading to autophagosome accumulation that supports viral assembly and modulates downstream mTOR signaling