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Igf1 CART-KO presented less staining of the cartilage degrading enzymes matrix metalloproteinase 13 (MMP13) and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) compared to control mice upon CHIR intra-articular injections (Supplementary Fig

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A key translational challenge will be to define the threshold and heterogeneity of GSH abundance across tumor types and microenvironmental niches, as this may critically influence treatment selectivity and resistance

DETOXIFICATION OF ROS FOR CELL SURVIVAL AND PROLIFERATION The glutathione synthesis pathway is another important anabolic target of Nrf2 (MacLeod et al., 2009)