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Metformin suppressed the folate cycle by inhibiting the dihydrofolate reductase [117], and utilization of the glycerol in Krebs cycle and gluconeogenesis by restraining the activity of bacterial glycerophosphate dehydrogenase resulting in decreased levels of dihydroxyacetone phosphate (DHAP) and elevated levels of nicotinamide adenine dinucleotide hydrogenasenicotinamide adenine dinucleotide (NADH-NAD) ratio in the bacterial cells [118]

Patients on chemotherapy or immunosuppressants should discuss glutathione with their oncology or transplant team, as antioxidant supplementation may theoretically interfere with certain therapeutic mechanisms

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How does glutathione IV therapy compare to oral supplements