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10.1126/science.272.5268.1606 209 ZhuangY.ZhangX.ZhangS.SunY.WangH.ChenY.et al (2025)

In a head-to-head trial, patients taking Tirzepatide 15mg lost an average of 22.5% of their body weight, whereas those taking Semaglutide 2.4mg (Wegovy) lost around 15%