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Nevertheless, the involvement of an hypomethylation cannot be ruled out, because in vitro studies suggest that a low concentration of homocysteine specifically inhibits endothelial cell regeneration and directly activates quiescent vascular smooth muscle cells through a mechanism involving decreased carboxymethylation of p21 ras (Lee and Wang, 1999

Cohens D , which estimates effect sizes by comparing one cell-type to all others, also proved suboptimal as it fails to guarantee specificity, i.e., it frequently selected probes with high effect size but negative GSS (SI Fig

The principle of the maintenance immunosuppression is regarding lifelong inhibition of immune cells activation and proliferation, such as the calcineurin inhibitor (tacrolimus) used in the Edmonton protocol, with the clear disadvantage that most of these agents show liver/kidney toxicity and have direct toxicity to cells