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Pre-marketing studies revealed an incidence of less than 1% of hemolysis and methemoglobinemia among 703 patients

doi: 10.1249/MSS.0000000000000623 132 Nascimento-GonalvesEMendesBALSilva-ReisRFaustino-RochaAIGamaAOliveiraPA

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Our study revealed negative regulation of LRP1-binding proteins (e.g., TIMP2, FN1, SERPINE2, MMP2, DCN, C1S, C1R, and CTSD) in chondrocytes exposed to H 2 O 2 , corroborating findings from LRP1 knockdown models [85], except for PSAP, which was downregulated in our study but upregulated in LRP1 knockdown models