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191 ZhangY.SunC.ZhaoC.HaoJ.ZhangY.FanB.et al (2019)

An example of a clinical syndrome secondary to mutations in this gene is SANDO (sensory ataxic neuropathy, dysarthria, ophthalmoparesis)

DNA methylation patterns are particularly affected, exposures to arsenic, cadmium, and certain pesticides have been linked to global hypomethylation as well as gene-specific hypermethylation that silences tumor suppressor pathways [38]