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Such changes in activity are commonly accompanied by clear signs of neurobehavioral alterations [83, 94, 95]

These limitations are further compounded by pharmacogenomic variability, where patient-specific genetic differences in drug-metabolizing enzymes (e.g., CYP450 isoforms) influence ART pharmacokinetics and toxicity profiles

Exogenous administration of SCFAs, particularly propionate and butyrate, significantly alleviated ocular inflammation in C57BL/6 EAU mice (66, 67)