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The MRN complex, consisting of MRE11, RAD50, and NBS1, plays a critical role in detecting and signaling DSBs ( Figure 2 Relative resistance to radiation-induced damage in the S phase is thought to be due in part to an elevated amount of DNA synthesis and repair enzymes, as well as increased intracellular levels of glutathione (a free radical scavenger) ( Historical perspectives on genetic associations with radiosensitivity In war, the victorious strategist only seeks battle after the victory has been won, whereas he who is destined to defeat first fights and afterwards looks for victory. - The Art of War , Sun Tzu A rational starting point to identify potential somatic molecular alterations in cancer cells which might be associated with increased radiosensitivity is to review early key observations linking individual genetic mutations to syndromes characterized by heightened radiation toxicity

Cederbaum, A

SLC3A1 is highly upregulated in breast cancers

at the end of drying the vacuum is broken with nitrogen, and the product is packaged in a closed bag