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It is believed that maintaining muscle mass in patients is important, since it has the ability to remove ammonia from circulation, while patients administered with enough protein observed a beneficial effect in the management of hyperammonemia and HE [92]

Cell cultures were supplemented with IGF-1 (10, 50, and 100 ng/mL), and the results showed that cell proliferation was more significant in all cell types after IGF-1 stimulation compared to the control group (received no IGF-1)