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Consensus sequence One approach that has been taken is to design vaccine antigens that are enriched for conserved T and B-cell epitopes either as a consensus sequence (which is the closest natural circulating sequence to a bioinformatically calculated consensus) or as a string of epitopes taken out of their natural context within the viral protein (Fig

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[2] However, unexplained elevation warrants investigation for underlying pathology, particularly hepatic or haematological disease

Published laboratory studies use a range of in-vitro concentrations and animal-model dosing depending on the experimental design, and these figures are specific to each study's protocol rather than a single standard amount