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In our study, we observed higher baseline levels of xanthine and hypoxanthine that decreased with the drug treatment

30,34 Additionally, the hepatocyte data from a study that quantified the abundance of proteins from an extensive and calibrated mass spectrometry dataset in isolated mouse primary liver cells 35 (hepatocyte, hepatic stellate cell, hepatic sinusoidal endothelial cell, Kupffer cell, and cholangiocyte) were used in this study

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International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use